Ehud Goldhammer
Technion Israel Institute of Technology, Israel
Title: The impact of exercise training on circulating S-Klotho in lean and obese coronary artery disease patients
Biography
Biography: Ehud Goldhammer
Abstract
Background: Klotho protein is a membrane-based circulating protein that regulates cell metabolism, as well as the lifespan modulating activity of Fibroblast Growth Factors (FGFs). Higher plasma circulating Klotho levels reduce cardiovascular risk, suggesting Klotho has a protective role in cardiovascular diseases. Recent studies have identified Klotho as a target gene for Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ), a master regulator of adipocyte differentiation and an adipogenesis-promoting factor. Aerobic exercise reduces the risk of cardiovascular events and mortality in patients with proven Coronary Artery Disease (CAD), thus, S-Klotho serum levels were assessed in lean and obese patients in order to find out whether exercise can modulate its activity.
Purpose: To assess the impact of 12 weeks exercise training program on S-Klotho in obese vs. lean CAD patients and to assess possible correlation between S-Klotho and diabetes.
Methodology: S-Klotho was assessed pre and post 12 weeks supervised aerobic exercise program (45 min/4-5 sessions/week) in 2 groups, Group-A=27 CAD patients with BMI≤29, age 59.7 years±2.2 SD and Gropup-B=13 CAD patients with BMI≥30, age 63 years±2.4 SD. All patients had a recent (<45 days) Aortocoronary By-Pass Surgery (CABG) years, Myocardial Infarction (MI) or Percutaneous Intervention (PCI). Assessment was done twice, prior to exercise program and at the end of 12 weeks intervention. Serum S-Klotho levels were analyzed using α-Klotho enzyme linked immuno-sorbent assay (ELISA) kit (IBL, Immuno-Biological Laboratories Co., Japan), Germany.
Results: No difference (p=0.21) was found at baseline for S-Klotho levels between the two groups, 730.49 pg/ml±201.20 SD and 715.33 pg/ml±209.11 SD respectively, while a difference was found following exercise intervention, 843.27 pg/ml±210.56 SD in the obese patients group compared to 767.51pg/ml±167.46 SD in lean patients group, p=0.037. S-Klotho had an inverse correlation with diabetes at baseline and following exercise program, r=-0.59 and -0.61 respectively (p<0.05).
Conclusion: Aerobic exercise may modulate S-Klotho activity, among obese patients in particular, thus conferring a possible mechanism for the enhanced survival of coronary artery patients engaged in aerobic exercise program. If it contributes to the obesity paradox it should be further investigated.